Ultra Instinct is a variation of Super God Fist used Goku in his Perfected Ultra Instinct and Perfected Ultra Instinct (Giant Form) forms.

With a furious roar, Goku flares his divine blue aura even higher as he rockets forward at unfathomable speeds, delivering a destructive punch to his target.

Goku uses the Ultra Instinct to attack Jiren after the Pride Trooper tried to attack the eliminated members of Team Universe 7. Driven by fury at Jiren's dishonorable act, the Saiyan rushed forward in the blink of an eye and smashed his fist straight into Jiren's face. The force of the punch was so strong that it created a beam, which pierced through several floating chunks of Kachi Katchin.

In the Galactic Patrol Prisoner Saga, Perfected Ultra Instinct Goku charges in to Moro (Earth absorbed) to destroy the crystal on his forehead but is halted by Moro's tendrils and has his energy drained. Later, he manages to finish the technique by using a massive ki avatar to hold Moro off, allowing him to close the gap and deliver the decisive blow.